Manchester United's hopes of salvaging their season in the Europa League suffered a stinging setback when they lost 2-1 at Danish side Midtjylland in the first leg of their last-32 clash on Thursday.
Ten-man Premier League leaders Leicester City lost at title-chasing Arsenal, while La Liga pacesetters Barcelona crushed Celta Vigo and Juventus took over from Napoli at the top of Serie A by edging their rivals.
Barcelona's Lionel Messi, Luis Suarez and Neymar motored past 100 goals for the season.
Real Madrid maintained their pursuit for the title by defeating Malaga 3-1 late on Saturday.
Juventus moved closer to a third straight Serie A crown with a 1-0 victory over Bologna, Paris St Germain won the French League Cup by defeating Olympique Lyon 2-1 and Benfica clinched a first Portuguese title since 2010.
Atletico Madrid moved a step closer to an unlikely Spanish title triumph when they battled back from a goal down to secure a 2-1 win at fourth-placed Athletic Bilbao in La Liga on Saturday.
Barcelona kept up the pressure on La Liga title rivals Atletico Madrid and Real Madrid when Lionel Messi struck from the penalty spot in a 1-0 win at Espanyol in Saturday's Catalan derby.
Lionel Messi broke a Spanish hat-trick record and Luis Suarez struck twice as a rampant Barcelona took over top spot in La Liga with a 6-1 hammering of Rayo Vallecano on Sunday.
Barcelona's Neymar scored twice and Luis Suarez was also on target as they reached their fourth King's Cup final in five years with a 3-1 win away to Villarreal on Wednesday that gave them a 6-2 aggregate victory.
Real Madrid closed to within two points of La Liga leaders Barcelona after demolishing nine-man Rayo Vallecano 10-2 while Atletico Madrid missed a chance to seize top spot outright by losing 1-0 at Malaga.
Real Madrid forward Cristiano Ronaldo is itching to get back into action in Wednesday's Champions League last 16, first leg at Schalke 04 after serving a three-match La Liga ban, coach Carlo Ancelotti said on Tuesday.
Real Madrid coach Carlo Ancelotti is confident Cristiano Ronaldo's three-match ban will be reduced to two so he can play in Saturday's La Liga game at home to Elche.
Barcelona's Lionel Messi was at the heart of another devastating attacking show.
Atletico Madrid tore apart city rivals Real Madrid 4-0 at home to open up the La Liga title race on Saturday in a triumph crowned by a spectacular overhead kick goal by Saul Niguez.
Real Madrid extended their unbeaten run to 25 matches and rejoined Barcelona and Atletico Madrid at the top of La Liga when Jese, Karim Benzema and Luka Modric scored in a 3-0 win at Getafe on Sunday.
The Portugal forward will miss Real's league games against Villarreal, Getafe and Elche but will be available for the King's Cup semi-final, first leg at home to holders Atletico Madrid later on Wednesday and the return game next week.
Diego Costa's season is getting better and better. The Atletico striker found the net again and took the Madrid team atop the La Liga table.
Real Madrid set up a King's Cup semi-final against holders Atletico Madrid or Athletic Bilbao when they beat Espanyol 1-0 in their quarter-final, second leg on Tuesday for a 2-0 aggregate success.
Pique and Pedro put Barcelona on top of the La Liga on goal difference with a 3-0 win over Malaga and Atletico Madrid won 4-2 at Rayo Vallecano to stay hot on their heels. Check out the footballers who shone over the weekend.
Valencia climbed above Atletico Madrid and Sevilla into third in La Liga when Alvaro Negredo came off the bench to score a late winner in a 3-2 home victory over his former club Almeria on Saturday.
Cristian Tello hit a hat-trick as Barcelona came from behind to win 4-1 in their King's Cup quarter-final first leg at Levante on Wednesday and Lionel Messi celebrated his 400th appearance for the Catalan side.
Real Madrid continued their impressive start to the new year with Karim Benzema giving them a 1-0 victory in the King's Cup quarter-final first-leg tie away to Espanyol on Tuesday.
Fernando Torres stole the show with a dramatic double as Atletico Madrid secured a battling 2-2 draw at Real Madrid on Thursday that dumped the holders out of the King's Cup 4-2 on aggregate.
Espanyol's Felipe Caicedo came off the bench and netted two late goals to secure a 2-0 win at home to 10-man Valencia on Tuesday that sent the Barcelona-based club through to the King's Cup quarter-finals 3-2 on aggregate.
Ballon d'Or winner Cristiano Ronaldo scored the opening goal as 10-man Real Madrid beat Osasuna 2-0 on Wednesday to qualify for the King's Cup quarter-finals 4-0 on aggregate.
Villarreal landed a stunning blow on a potential rival for a European qualification berth when Giovani dos Santos and Ikechukwu Uche each struck twice in a 5-1 drubbing of Real Sociedad in La Liga on Monday.
Alexis Sanchez hit a hat-trick as Barcelona swept aside Elche 4-0 to return to the top of La Liga on goal difference ahead of Atletico Madrid on Sunday.
A three-pronged investigation will take place into alleged state aid for several La Liga clubs, including Real Madrid and Barcelona, the European Commission said on Wednesday.
The European Commission will begin disciplinary action against seven Spanish clubs including Real Madrid and Barcelona over possible illegal state aid, Spanish foreign minister Jose Manuel Garcia Margallo said on Monday.
UEFA wants consistent sanctions against match-fixing across Europe and has drafted an 11-point plan to help make that happen, general secretary Gianni Infantino said on Thursday.
Barcelona's 2-1 loss at Ajax Amsterdam in the Champions League last week was down to a lack of intensity while Sunday's 1-0 reverse at Athletic Bilbao in La Liga exposed their relative physical frailty.
Real Madrid secured a club record 16th straight victory when Karim Benzema and Gareth Bale struck in a laboured 2-1 win at Malaga on Saturday that put them five points clear of second-placed Barcelona in La Liga.
Lionel Messi will be working "full time" to shake off the hamstring injury sustained on Sunday that will sideline him for six to eight weeks, Barcelona's Argentine World Player of the Year said on Tuesday.
Billed as the most high-profile clash in chess history in more than 40 years, the World Chess Championship match -- between defending champion Viswanathan Anand and challenger Magnus Carlsen of Norway -- begins in Chennai on Saturday, with the experts divided over who will walk away with the coveted title.
Celta Vigo thrashed Barcelona 4-1 on Wednesday with Iago Aspas hitting a double.
Paris St Germain's Zlatan Ibrahimovic scored his first Ligue 1 goal this season before missing a penalty as they beat En Avant Guingamp 3-0 to extend their lead to four points on Tuesday.
Villarreal tightened their grip on fourth place in La Liga when Nigerian forward Ikechukwu Uche's last-gasp strike snatched a 1-0 win at fellow promoted side Elche on Monday.
Barcelona extended their near-perfect start to the season when Alexis Sanchez tapped in at the far post from Neymar's clever assist to secure a 1-0 win at home to city rivals Espanyol in La Liga on Friday.
Atletico Madrid kept pace with leaders Barcelona and restored their five-point lead over third-placed city rivals Real when Diego Costa and David Villa each scored a penalty in a 2-1 win at Granada in La Liga on Thursday.
While Gareth Bale is fully expected to regain his place in the Real Madrid side when he returns from injury, team mate Isco is making the most of his chance to prove his worth on the pitch.